过敏性哮喘血浆可溶性白介素2受体与嗜酸性细胞、嗜碱性细胞、总IgE关系的研究

Relationships between Plasma SIL-2R and Eosinophil Count,Basophil Count,IgE in Allergic Asthma

３０例过敏性哮喘患者和２４例正常人分别被检测了血浆可溶性白介素２受体（ＳＩＬ－２Ｒ）、ＩｇＥ和全血嗜酸性细胞、嗜碱性细胞值，可观察到哮喘组ＳＩＬ－２Ｒ平均值为２３２０ｐｇ／ｍＬ，明显高于正常组的１７６０．９４ｐｇ／ｍＬ）（Ｐ＜０．０５），表明哮喘组Ｔ细胞呈活化状况。哮喘组的嗜酸性细胞、嗜碱性细胞、ＩｇＥ增高的百分率分别为６３．３３％（１９／３０）、６６．６７％（２０／３０）和３６．６７％（１１／３０），均明显高于正常组的４．１７％（１／２４）．哮喘组中有８例ＳＩＬ－２Ｒ值大于３０００ｐｇ／ｍＬ，其中４例（５０％）嗜酸性细胞、ＩｇＥ２项检测及嗜酸性细胞、ＩｇＥ、嗜碱性细胞３项检测均增高，且病情较重，而在ＳＩＬ－２Ｒ≤３０００ｐｇ／ｍＬ的２２例中，其２项、３项检测同时增高者仅３例（１３．６４％），２组差异显著（Ｐ＜０．０５），提示血浆ＳＩＬ－２Ｒ的检测对研究哮喘的发病机理和反映病情严重状况均有意义。

Plasma SIL-2R,blood eosinophil count, basophil count were detected in 30 allergic asthmatics,as well as in 24 healthy controls withoout asthma. It was showed that the mean level of SIL-2R in asthmatics was 2320 pg/mL,being much higher than that of 1760. 94 pg/mL in the normal control group (P<0. 05). It indicated that the T lymphocyte was activated in allergic asthma. The elevation rate of eosinophil count, basophil count and IgE was 63. 33% (19/30), 66. 67% (20/30), and 36. 67% (11/30), respectively in asthma group, being much higher than 4. 17%(1/24), 4. 17% (1/24 )and 4. 17%(1/24), respectirely in the control group (P<0. 05). There were 8 asthmatics with SIL-2R>3000 pg/mL,and among them 4 cases (50%) showed both elevation of eosinophil count and IgE,or elevation of three items including eosinophil count,basophil count,IgE, but only 3 cases showed the same elevation in 22 asthmatics with SIL-2R≤3000 pg/mL. There is significant difference between these two groups (P<0. 05).