^(153)Sm-EDTMP与伊班膦酸钠联合治疗肺癌骨转移临床观察

Effect of ^(153)Sm-EDTMP combined with ibandranate in treatment of osseous metastasis of lung cancer

目的探讨153Sm-EDTMP内放疗与伊班膦酸钠(艾本)全身用药相结合治疗肺癌骨转移的临床疗效。方法96例肺癌骨转移患者随机分为2组,153Sm-EDTMP内放疗加伊班膦酸钠静脉滴注48例(治疗组),单用153Sm-EDTMP核素治疗组48例(对照组),比较2组止痛效果、活动能力、生活质量改善、溶骨病灶的修复及毒副作用。结果治疗组疼痛缓解率为93.75%,对照组疼痛缓解率为66.67%,2组间比较有显著差异(P<0.05);2组患者不良反应的发生率无显著差异(P>0.05)。结论153Sm-EDTMP与伊班膦酸钠联合治疗肺癌骨转移,具有止痛、改善活动能力、提高生存质量并能有效修复溶骨性病灶的疗效。

Objective To evaluate the clinical efficacy of ^153Sm-EDTMP combined with ibandranate in treatment of osseous metastasis of lung cancer. Methods Ninty-six patients with osseous metastasis of lung cancer were randomly divided into two groups. The patients were received intervenous drop infusion of ^153Sm-EDTMP and ibandranate in treatment group （n = 48）. The patients were received therapy with ^153Sm-EDTMP in control group（ n = 48）. The different of effect of odynolysis,locomotor activity, improvement of quality of life,recovery of osteolysis,toxical and adverse reaction between two group was compared. Results The odynolysis rate of treatment group was 93.75% while that of control group was 66.67%. There was significant difference between two groups（P 〈0.05 ）. The incidence of adverse reaction between two groups was no significant different （P 〉0. 05 ）. Conclusion The treatment of ^153Sm-EDTMP combined with ibandranate in treatment of osseous metastasis of lung cancer is effective for relieving pain,improvement locomotor activity,improvement of quality of life, recovery of osteolysis.