倍他洛克加钾镁极化液预防阿霉素所致心脏毒性疗效分析

Efficacy of combination of polarized solution of Ka and Mg with Betaloc for treatment of cardiac muscle toxicity caused by Adriamycin

目的分析倍他洛克加钾镁极化液预防阿霉素的心脏毒性的效果。方法120例肿瘤患者,随机分为2组,对照组60例常规预处理后用含阿霉素方案化疗。治疗组60例,给予倍他洛克加钾镁极化液加常规预处理后用含阿霉素的方案化疗,比较2组心脏毒性的发生情况。结果治疗组心脏毒性发生率8.33%,心电图改变发生率13.33%;对照组心脏毒性发生率33.33%,心电图改变发生率35.00%;治疗组心脏毒性发生率、心电图改变发生率明显低于对照组(P<0.01)。结论倍他洛克加钾镁极化液治疗肿瘤患者能够降低阿霉素的心脏毒性。

Objective To analyze of efficacy of combination of polarized solution of Ka and Mg with Betaloc for treatment of cardiac muscle toxicity caused by Adriamycin. Methods One hundred and twenty patients with tumors were divided into two groups. The patients in control group were treated with chemotherapy including Adriamycin,the patients in treatment group were performed with protocol of pretreatment with polarized solution of Ka and Mg with Betaloc followed by Adriamycin. Occurrence of cardiac muscle toxicity in two groups was compared. Results The incidence of cardiac muscle toxicity of the treatment group was 8.33% ,The incidence of arrhythmia of the treatment group was 13.33% ,and the incidence of cardiac muscle toxicity of the control team was 33.33% ,the incidence of arrhythmia of the control group was 35.00%. Incidence of cardiac muscle toxicity and arrhythmia in treatment group was obviously lower than that in control group（P 〈 0.05 ）. Conclusion Combination of polarized solution of Ka and Mg with Betaloc can decrease cardiac muscle toxicity caused by Adriamycin.