疫苗时代麻疹母传抗体追踪观察及北京市麻疹控制策略的分析

A FOLLOW-UP OBSERVATION ON MATERNAL- TRANSFERRED MEASLES ANTIBODY IN THE VACCINE ERA AND A MEASLES CONTROL STRATEGY IN BEIJING

针对北京市近年麻疹发病率上升，发病年龄向 ２～７月龄婴儿和２０岁以上成人转移等新情况，本文对麻疹的流行病学、流行因素、人群免疫状况进行了分析研究，采用配对与追踪观察方法对婴儿母传麻疹抗体进行了调查研究。根据调研结果，着重对近年麻疹发病年龄变化原因、疫苗时代的初免月龄以及有争议的再免问题进行了深入探讨，进而提出适当调整本市麻疹疫苗免疫程序，提前初免，婚前再免，坚持原有再免方案的高水平控制或消除麻疹的新策略。

In recent years. there had ho some increasing of measles incidence (0.51/100,000 in 1990 to l.73/100,000 in 1994) in Beliing and the patients' age moved to 2-7 months old infants and the adults over 20 years old. Infection of pregnant women and mother-to-infant infections also occurred. We have studied the collected data of measles epidemiology, epidemic factors and im mune status of the population. And, besides, a follow-up investigation on maternal-transferred measles antibody titer and its sustaining bine in infants was also proceeded According to the re- sults gained, we inquired into the cause for age shifting phenomenon of measles infection, the first vaccinatd age of infants and the proper revaccinated time which has remained to be a question quarrelling in the past. Going further, we offered a modified vaccination schedule,,that is to move up the data for first vaccination to infants, to revaccinate before marriage, to persist on the originally decided revaccinated schedule. This new strategy will attain a high level in contolling or eliminating measles.