多潘立酮干预早产儿喂养不耐受30例疗效观察

Observation of therapeutic effect of domperidone for trentment of 30 preterm infants with fedding intolerance

目的探讨多潘立酮干预早产儿喂养不耐受的临床效果。方法54例喂养不耐受早产儿随机分为干预组30例和对照组24例。对照组给予保温、体位疗法、部分静脉营养等常规疗法。干预组在对照组治疗基础上口服或鼻饲多潘立酮混悬液0.2-0.3 ml.kg-1,每8 h 1次,喂奶前30 min给予,疗程3-5 d。结果干预组患儿病程和呕吐时间明显短于对照组(P<0.05),平均增加体重和每日增加奶量明显高于对照组(P<0.05);2组患儿均未出现明显不良反应。结论多潘立酮能提高早产儿喂养耐受性,且无明显副作用。

Objective To explore the clinical effect of domperidone on 30 preterm infants with fedding intolerance. Methods Fifty-four preterm infants with fedding intolerance were randomly divided into the intervention group（ n = 30） and control group（ n = 24） ,the infants of the control group were performed with conventional therapy such as keeping warm,positional therapy, partial parenteral nutrition and so on;the infants of the intervention group were given domperidone suspl 0.2～0.3 ml· kg^-1 by peroral administration or nasal feeding before feeding every 8 hours a day, for 3 - 5 days,30 min before feeding. Results The course of disease and the vomitive time were shorter in the intervention group than those in the control group, the average weight gain and the amount of daily milk were higher in the intervention group than those in the control group. There wasn＇t obvious adverse effect in two groups. Conclusion Domperidone can improve the fedding tolerance of preterm infants and hasn＇t obvious side effect.