促红细胞生成素与脑损伤保护作用

The protective effect of erythropoietin on brain injury

促红细胞生成素(EPO)是由肾脏分泌的内源性细胞因子。各种脑细胞均有EPO及EPO受体(EPOR)的表达。EPO可作为神经保护因子,通过抗兴奋性氨基酸毒性、抗细胞凋亡、增加细胞钙内流、抑制一氧化氮(NO)合成等作用实现对脑损伤的保护作用。作者通过综述近年来国内外相关文献,以了解促红细胞生成素及其受体的产生、结构及其在脑损伤中的保护机制。

Erythropoietin （EPO） is a kind of endogenesis cell factor which was excreted by the kidney. Each kind of brain cell has found EPO and its receptor（EPOR） ,EPO may take one kind of neuro-protective factor. It has been shown that EPO exerted protective effect on brain injury, and its mechanisms include anti excitatory amino acids toxicity, anti cell apoptosis,promoting cell calcium flows-in, inhibiting nitric oxide formation, etc. Recent domestic and foreign papers were reviewed for learning the development of EPO and its receptors ,its structure and protective mechanism on brain injury.