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碱性成纤维细胞生长因子结合静脉套接修复正中神经缺损 被引量:4

Reparation of peripheral median nerve defect with basic fibroblast growth factor(bFGF) combined with autogenous vein graft conduit
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摘要 目的探讨碱性成纤维细胞生长因子(bFGF)结合静脉套接修复周围神经缺损的效果。方法8例4cm以内正中神经缺损,取自体静脉套接并对断面进行处理,静脉内注入碱性成纤维细胞生长因子0.5ml,术后检查Tinel征、神经肌电图,受损靶肌肉注射0.2mlbFGF。结果随访10月~2年,3例神经缺损1~1.9cm,神经功能评定为优。2例神经缺损2~2.9cm,神经功能评定为优。2例神经缺损3.0~3.5cm,神经功能评定为优1良1。1例神经缺损3.6~4.0cm,神经功能评定为良。所有病例神经再生速度大于2mm/天。结论碱性成纤维细胞生长因子(BFGF)结合静脉套接是修复神经缺损的有效方法,能明显促进神经再生。 Objective To explore the effect of basic fibroblast growth factor (bFGF) combined with autogenous vein graft conduit on peripheral nerve regeneration. Methods 8 cases with median nerve defect within 4 cm was bridged by autogenous vein graft conduit. 0.5 ml bFGF solution was intravenoudy injected. Target muscle was injected with 0.2ml bFGF. Post-operative function was evaluated by Tinel sign and electromyography. Results All cases were followed up 10-24 months. According to the system of peripheral nerve function evaluation, 3 cases with 1-1.9cm nerve defect were considered excellent, 2 cases with 2-2.9cm nerve defect were considered excellent. In 2 cases with 3-3.5cm nerve defect, one was considered excellent and aother one was considered good. Another case with 3.5-4cm nerve defect was considered good. The nerve regeneration velocity was more than 2mm per day in all cases. Conclusion bFGF combined with autogenous vein graft conduit can markedly promote nerve regeneration.
出处 《浙江创伤外科》 2007年第1期1-2,共2页 Zhejiang Journal of Traumatic Surgery
基金 温州市科技发展项目(S2001A12)
关键词 碱性成纤维细胞生长因子 静脉套接 周围神经缺损 Basic fibroblast growth factor Vein graft conduit Median nerve defect
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  • 1洪光祥,王发斌.自体静脉移植修复周围神经缺损的疗效观察[J].中华手外科杂志,1993,9(1):10-11. 被引量:4
  • 2吴德升,赵定麟,何北平,杜晓冰.修复周围神经缺损的组织工程研究[J].生物医学工程学杂志,1997,14(2):108-110. 被引量:20
  • 3Gimenez GG, Cuevas P. Fibroblast growth factors, proteins with a broad spectrum of biological activities. Neurol Res, 1994, 16:313-316.
  • 4Okada Ban M, Thiery JP, Jouanneau J. Fibroblast growth factor-2. Int J Biochem Cell Biol, 2000, 32:263-267.
  • 5Jungnickel J, Claus P, Gransalke K, et al. Targeted disruption of the FGF-2 gene affects the response to peripheral nerve injury. Mol Cell Neurosci, 2004, 25:444-452.
  • 6Abraham JA, Mergia A, Whang JL, et al. Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor. Science, 1986, 233:545-548.
  • 7Kinsella L, Chen HL, Smith JA, et al. Interactions of putative heparin-binding domains of basic fibroblast growth factor and its receptor, FGFR-1, with heparin using synthetic peptides. Glycoconj J, 1998, 15:419-422.
  • 8Dow JK, deVere White RW. Fibroblast growth factor 2: its structure and property, paracrine function, tumor angiogenesis, and prostate-related mitogenic and, oncogenic functions. Urology, 2000, 55:800-806.
  • 9Aoyagi A, Nishikawa K, Saito H, et al. Characterization of basic fibroblast growth factor-mediated acceleration of axonal branching in cultured rat hippocampal neurons. Brain Res, 1994, 661:117-126.
  • 10Yan RT, Wang SZ. Differential induction of gene expression by basic fibroblast growth factor and neuron D in cultured retinal pigment epithelial cells. Vis Neurosci, 2000, 17:157-164.

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