克罗米芬延长法诱导排卵治疗不育

Induction of ovulation with incremental clomiphene therapy for treatment of infertility

６０年代以来，克罗米芬已成为诱导排卵的首选药物，但仍有２０％～３０％患者对常规应用克罗米芬无反应。为此我们采用克罗米芬延长法诱导排卵２６例，共７５个周期，结果：排卵有效率，按例为８０％（２１／２６），按周期为６５％（４９／７５）；妊娠６例共７次，妊娠率２９％（６／２１）。认为，此法简单、有效、安全，无一例发生卵巢过度刺激综合征。适用于常规用克罗米芬无效但雌激素水平正常患者。

bjective:Use of incremental.clomiphene therapy in the induction of ovulation for the treatment of infertility after failure with regular clomiphene for 5 days.Methods:Progressive incremental clomiphene therapy with a variable duration of clomiphene treat-ment from 7-9-11 days plus hCG 10 000IU im.was used in 26 cases after failure with regular clomiphene 100mg/day for 5 days for 3 cycles.Hormone determinations were done to find the cause of anovulation BBT,ultrasound and cervical mucus for monitoring ovulation. Results:The successful ovulation rate arnong 26 cases was 80%(21/26) and 6 cases got pregnant 7 times,a pregnancy rate of 29%(6/21).This method should be used only in cases with normal estrogen level.Conclusion:Progressive incremental clomiphene therapy is a simple,effective and safe method for induction of ovulation after failure with regular method of clomiphene therapy.