干细胞移植治疗时间窗与临床疗效的荟萃分析

Timing-window and therapeutic effects of stem cell transplantation: A Meta-analysis

目的:探讨寻找干细胞移植治疗急性心肌梗死的最佳移植治疗时间,指导临床应用,提高临床疗效。方法:应用计算机检索medline2000-01/2006-05文章,检索词为:"stem cell transplantation and/or acute myocardialinfarction(AMI)and/or chronic heart failure or ischemic cardiomyopathy",限定文章语言种类为English;同时计算机检索中国期刊全文数据库,相同时间的文章,检索词:"干细胞移植治疗,干细胞移植与急性心肌梗死,干细胞移植治疗与心力衰竭或慢性缺血性心肌病",限定文章语言种类为中文。共检索到300余篇与主题有关的文献,其中12篇有价值的文章见参考文献。移植时间取平均值,并按射血分数值和P值进行列表、作图。对干细胞移植时间与射血分数值之间的关系进行分析。结果:在急性心肌梗死后2～5d和9d以后进行干细胞移植治疗疗效较24h内及6～8d为好。结论:干细胞移植治疗急性心肌梗死的移植时间与临床疗效之间可能存在一定的相关性。经冠脉注入干细胞比经静脉或经心内膜下注入可以更好地改善左室功能,但还需要进一步的临床资料证实。

AIM： To explore the best time of stem cells transplantation for treating acute myocardial infarction （AMI）, instruct clinical application and increase curative effects. METHODS： We searched the publication in English of medline database from January 2000 to May 2006 with key words of ＂stem cell transplantation and/or acute myocardial infarction （AMI） and/or chronic heart failure or ischemic cardiomyopathy＂ on computer. We also searched the related publication from China Journal Full-text Database （CJFD） with same key words in Chinese and in same duration. Totally over 300 papers correlated with this title was found out, but only 12 papers ware included （see references）. The time of transplantation was counted on average, and all data was listed in table including ejection fraction （EF） value and P value, finally the relationship of the time of stem cell transplantation with EF values was analyzed. RESULTS： The curative effect of stem cell transplantation for treating AMI was better within the duration of 2-5 days or after 9 days of onset than within 24 hours or 6-8 days after onset. CONCLUSION： There is a certain correlation of the time of stem cell transplantation for treating AMI with its curative effect, and heart function will be improved significantly by coronary artery injection of stem cell transplantation, compared with intravenous injection or transendocardial injection, which still need further study.