细胞角蛋白19与胰腺干细胞(英文)

Cytokeratin 19 and pancreas stem cells

目的:综合分析细胞角蛋白19与胰腺干细胞的关系。资料来源:应用计算机检索Medline及Ovid2000-01/2006-05有关细胞角蛋白19与胰腺干细胞关系的文献,检索词"Cytokeratin,Pancreas,Stem cells,Marker,Differentiation"并限定文章语言种类为English。资料选择:对检索到的细胞角蛋白19与胰腺干细胞关系的相关信息进行整理,选取针对性强的文章,同一领域的文献则选择近期发表或权威杂志的文章。资料提炼:共检索到86篇相关文献,其中35篇文章符合要求,排除51篇。资料综合:胰腺干细胞具有多向分化功能,细胞角蛋白19在胰腺干细胞中有阳性表达,是胰腺干细胞的分子标志物,这对进一步了解胰腺干细胞的生物学特性,对胰腺干细胞的分离、纯化及转型定向分化为胰岛细胞具有重要意义,胰腺干细胞的移植为糖尿病的治疗开辟了道路。结论:胰腺干细胞在分化过程中有细胞角蛋白19表达,细胞角蛋白19是胰腺干细胞的标志物。

BACKGROUND： To synthetically analyze the correlation between cytokeratin 19 and pancreas stem cells DATA SOURCES： References about the correlation between cytokeratin 19 and pancreas stem cells were retrieved in Medline and Ovid database with the key words of ＂cytokeratin, pancreas, stem calls, marker, differentiation＂ in English from January 2000 to May 2006. STUDY SELECTION： Literatures about the correlation between cytokeratin 19 and pancreas stem calls were retrieved and those characterized by strong pertinency, published in the near future and selected from authoritative journals were selected in this paper. DATA EXTRACTION ： Among 86 articles, 35 of them met the inclusion criteria and 51 were excluded DATA SYNTHESIS： Pancreas stem cells are characterized by multi-directional differentiation. Cytokeratin 19 has a positive expression in pancreas stem cells and a molecular sign of pancreas stem cells. This provides a new way to further understand bionomics of pancreas stem cells, study separation, purification, transconformation and direction differentiation to islet cells, and treat diabetes mellitus with transplantation of pancreas stem cells. CONCLUSION ： Expression of cytokeratin 19 is observed during the differentiation of pancreas stem calls and cytokeratin 19 is a sign of pancreas stem calls.