阻塞性睡眠呼吸暂停综合征对犬心血管功能的影响

Effects of Obstructive Sleep Apnea Syndrome on the Cardiovascular Function in Dogs

目的:探讨阻塞性睡眠呼吸暂停综合征(OSAS)对犬心血管功能的影响。方法:建立OSAS犬模型,人为干预使犬出现类似OSAS患者症状,干预时间为3个月。干预前和干预后,取血用ELISA法检测犬血中白介素-6(IL-6)浓度;用超声心动图检测犬的心功能相关指标:左室射血分数(LVEF)、左室内径缩短率(FS)、每搏输出量(SV)、心率(HR)、舒张早期充盈峰值流速和舒张晚期充盈峰值流速的比值(E/A)。结果:与干预前相比较,3月后犬血中IL-6值明显升高(P<0.01);LVEF、FS、SV、HR、E/A值均降低(P<0.05)。结论:OSAS可能是一个慢性炎性过程,不仅对血管内皮功能造成影响,而且其慢性长期缺氧对心脏收缩和舒张功能也会造成影响。

Objective： To study the effects of obstructive sleep apnea syndrome （OSAS） on the cardiovascular function in dogs. Methods： Canine models of OSAS were established, and all dogs showed the symptoms similar to those observed in patients with OSAS. Before and after the experiment, the serum interleukin-6 （IL-6） levels of each dog was measured by ELISA respectively, and the cardiovascular function were measured by the echocardiography, such as left ventricle ejection fraction （LVEF）, fractional shortening of left ventricle（FS）, stroke volume （SV）, heart rate （HR） and E/A. Results： The serum IL-6 levels increased significantly （P〈0. 01） and LVEF, FS, SV, HR and E/A all decreased compared with those three months ago （all P〈 0.05）. Conclusion： The OSAS is a chronic inflammation and injuries on the endothelial function. It may affect the cardiac systolic and diastolic function because of the long chronic hypoxia.