喉癌癌周毛细淋巴管超微结构特点与颈淋巴转移

The correlation between ultrastructure of lymphatic capillary and neck lymph node metastasis laryngeal carcinoma

目的:研究喉癌癌周毛细淋巴管的超微结构特点与颈淋巴转移的关系。方法:采用透射电镜技术对8例正常喉喉黏膜组织及12例喉癌癌周毛细淋巴管的超微结构特点进行了观察和比较。结果:癌周毛细淋巴管较正常喉组织显著扩张,有大量的内皮细胞连接开放,基膜缺乏更加严重,部分毛细淋巴管内皮细胞被破坏,甚至完全断裂。结论:癌周毛细淋巴管的超微结构特点是喉癌经淋巴道转移的重要因素,因而为进一步探讨喉癌颈淋巴结转移的机制以及防治提供了理论依据。

Objective： To study the correlation between ultrastructure of lymphatic capillary in pericancerous tissue and neck lymph node metastasis in laryngeal carcinoma. Method： Transmission electronic microscope was applied to observe and compare ultrastructure of lymphatic capillary in 8 normal laryngeal epithelial tissue and 12 pericancerous tissue of laryngeal cancer. Result：Lymphatic capillary of pericancerous tissue was significantly dilated compared with normal laryngeal tissue. A large amount of endothelial cell junction was open and devoid of basement membrane. Some endothelial cells of lymphatic capillary were destroyed or broken completely. Conclusion： Ultrastructure of lymphatic capillary in pericancerous tissue is an important factor of laryngeal cancer metastasis through lymphatic system. This research offers theoretic basis for laryngeal carcinoma metastasis mechanism and prevention.