坎地沙坦和苯那普利治疗高血压病的对照研究

Comparative study of candesartan and benazepril in treatment of essential hypertension

目的 评价坎地沙坦同苯那普利治疗高血压病的疗效及其对血脂、肾功能的影响及副作用。方法 坎地沙坦组59例给予坎地沙坦剂量8-16nv／d，苯那普利组56例服用苯那普利，剂量10-20mg／d，均治疗6周。治疗前后所有参与者测血压和测定胆固醇、三酰甘油、肾功能。结果 监测血压显示坎地沙坦组降压与苯那普利组无差异，对胆固醇、三酰甘油没有影响，有降低尿酸的作用，与苯那普利组相比，咳嗽发生率低，并能改善肾功能及保护内皮细胞功能。结论 坎地沙坦同苯那普利治疗轻、中度高血压病安全、有效，对血脂、肾功能无影响。坎地沙坦有降低尿酸的作用，咳嗽发生率低。

AIM To compare the therapeutic effects of candesartan and benazepril in the treatment of essential hypertension. METHODS Fifty nine patients were treated with candesartan （8 - 16 mg/d） while fifty six patients were treated with benazepril （10 -20 mg/d） for six weeks, and the results were compared. Blood pressure was monitored and blood lipid, urea nitrogen, creatinine, urine acid, blood α1-MG and urine α1-MG, urine Alb and plasma renin activity （PRA） were examined before and after the treatment. RESULTS Blood pressure monitoring showed no difference in the antihypertensive effect between the two drugs. Candesartan had no effect on TG and TC but it decreased the level of urine acid. The incidence of cough was lower in candesartan treated group. Candesartan also decreased blood α-MG and urine α1-MG and urine Alb （ P 〈 0.01 ）, while plasma renin activity （PRA） increased （ P 〈 0.01 ）. CONCLUSION Candesartan is effective and safe in the treatment of hypertension and it can decrease the level of urine acid of blood. The incidence of cough is lower when candesartan is administrated.