基质金属蛋白酶-9与脑缺血损伤的关系研究进展

New development of relationship of atrixmetallo proteinases-9 (MMP-9) and cerebral ischemia

基质金属蛋白酶-9(MMP-9)能降解和重塑造细胞外基质,破坏血—脑屏障,导致脑损伤和脑水肿。了解MMP-9在脑缺血再灌注损伤中的作用、表达、影响其表达的因素及有关抗体的研究及应用,可以为脑梗死的早期诊断、预防和治疗开辟新的途径。

Matrix metalloproteinases-9 （MMP-9） can degrade and remode extracelluar matrix, destruct the blood-brain barrier. These led to the cerebral injury and brain edema. Understanding of the expression and role of MMP-9, the factor affecting its expression and the application of MMP-9 antibody during cerebral ischemic/repeffusion injury is important. It can find new appraches in the early diagnosis, prevention, and treatment.