通心络胶囊对糖尿病自主神经病变心率变异的影响

Effect of Tongxinluo capsuls on heart rate variability of diabetic autonomic neuropathy

目的观察通心络胶囊对糖尿病自主神经病变(DAN)患者的治疗作用。方法DAN病人126例,随机分为治疗组和对照组,治疗组予通心络胶囊3粒,每日3次,口服,共12周;对照组:给予弥可保500μg,每日3次,口服,共12周。结果治疗组多汗、腹泻、便秘、排尿障碍、体位性低血压改善优于对照组(65.5%比50.0%、61.5%比46.2%、68.8%比24.4%、71.4%比53.8%、50.0%比37.5%);心脏自主神经测试治疗组优于对照组(P<0.05)。且未见明显副作用。结论通心络胶囊对糖尿病自主神经病变有一定疗效。

[Objective] To observe the therapeutic effects of Tongxinluo capsuls in the treatment of diabetic autonomic neuropathy （DAN）, [Methods] 126 DAN patients were randomly divided into treatment group and control group, In treatment group, 63 cases were treated with Tongxinluo capsuls 3 grain orally three times a day for twelve weeks. In control group, 63 cases were treated with Methylcobalamin 500 μg orally three times a day for twelve weeks. [Results] Twelve weeks after the treatment, hyperhidrosis, diarrhea, constipation, dysuria and postural hypotension showed better response in the treatment group than in the controls group （65.5%vs50.0%, 61.5%vs46.2%, 68.8%vs24.4%, 71.4%vs53,8%, 50.0%vs37.5%）. Tongxinluo capsuls also benefited cardiac autonmic nerve function than the control group （P 〈0.05）. No obvious side effects were found. [Conclusions] Tongxinluo capsuls has some effect in the treatment of diabetic autonomic neuropathy.