磷钨酸/活性炭催化合成7-羟基-4-甲基香豆素

Catalytic Synthesis of 7-Hydroxy-4-Methyl Coumarin by Activated Carbon Supported Phosphotungstic Acid

7-羟基-4-甲基香豆素是一种重要的医药化工中间体.笔者研究了活性炭负载磷钨酸催化合成7-羟基-4-甲基香豆素的反应,考察了反应的各种影响因素,通过单因素实验得到合成7-羟基-4-甲基香豆素的最佳工艺条件:n(间苯二酚):n(乙酰乙酸乙酯)=1∶1;反应温度为100℃;反应时间为3 h;磷钨酸/活性碳的负载比为22.3%,用量为0.15 g;收率达74.3%.

7 - hydroxy - 4 - methyl coumarin as chemical or medical intermediates is very important in industry. The synthesis of 7 - hydroxy - 4 - methyl coumarin was studied using activated carbon supported phosphotungstic acid as catalyst. The effects of various factors on the reaction were discussed in detail. The optimum conditions were obtained for industrialization. The molar ratio of resorein to acetyl ethyl acetate was 1 ： 1, reaction temperature is 100 ℃, reaction time is 3 h, the amount of loaded phosphotungsic acid is 22.3%, the catalyst dosage is 0.15 g. The yield reached 73.4%.