摘要
采用间隔２４小时两次注射大肠杆菌内毒素方法复制家兔急性肺损伤模型，检测血浆、肺组织及支气管肺泡灌洗液（ＢＡＬＦ）中白细胞介素８（ＩＬ－８）、硝酸盐／亚硝酸盐（ＮＯ２／ＮＯ３）水平及有关指标改变，观察中药制剂热毒清（ＲＤＱ）对家兔内毒素性肺损伤的保护作用。发现ＲＤＱ可降低肺系数及通透指数，减少ＢＡＬＦ中白细胞计数；ＩＬ－８、ＮＯ２－／ＮＯ３－水平、酸性磷酸酶（ＡＣＰ）活性亦显著降低（Ｐ＜０．０１），肺组织学损伤减轻。证实ＲＤＱ对内毒素所致的家兔急性肺损伤具有一定的保护作用。
cutelunginjurymodelofrabbitswithdissminatedintravascularcoagulation(DIC)wasmadebyinjectionofE.Coliendotoxintwiceat24-hourinterval.lnterleukin-8(IL-8),nitrite/*妌itrate(NO2-/NO3-.)levelsandchangesofcertainparametersinplasma,andlungtissueandbronchoalveolarlavagefluid(BALF)weredetermined.TheaimwastostudytheeffectsofRDQinjectiononendotoxin-inducedacutelunginjury.Ourexperimentfoundthatpretreat-mentwithRDQresultedinmarkedreductionoflunginjury,lungpermeabilityindex(LPl),WBCinBALF,theIL-8,NO2-/NO3-level,andacidphosphatase(ACP)activities(P<0.01).postmortemexaminationrevealedthatRDQattenuatedthehistopatholoicalchanges.TheresultsuggestedthatRDQmighthavepotentialpreventiveandtherapeuticeffectonen-dotoxin-inducedacutelunginjuryinclinicalpractice.
出处
《中国中西医结合外科杂志》
CAS
1996年第6期455-459,共5页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
热毒清
肺损伤
内毒素
中医药疗法
Reduqing,interleukin-8,nitricoxide,lunginjury,endotoxin
