围产期窒息新生儿血清肌酸磷酸激酶的临床意义探讨

The study of the significances of serum creatine phosphokinase in asphyxiated newborns

目的:探讨围产期窒息新生儿血清肌酸磷酸激酶(CPK)的临床意义。方法:用酶偶联测定法分别检测122例窒息新生儿及20例健康对照组24h内血清CPK水平并进行分析。结果:窒息组血清CPK均高于对照组(P<0.01);42例窒息儿并发新生儿缺血缺氧性脑病(HIE),其CPK值明显高于其它未并发HIE的窒息新生儿(P<0.01)。其中16例并发中-重度HIE,26例并发轻度HIE,并发中-重度HIE的CPK值明显高于并发轻度HIE的窒息儿(P<0.01);39例窒息新生儿并发多脏器功能不全(MODS),并发MODS的窒息新生儿的血清CK明显高于未并发MODS的窒息新生儿。结论:测定围产窒息新生儿的血清CPK有助于预测窒息新生儿并发HIE及MODS的可能性,有助于HIE的临床分度。

Objective： To investigate the significances of serum creatine phosphokinase （CPK） in asphyxiated newborns. Methods： Serum CPK levels of 122 asphyxiated neonates and 20 normal neonates were detection. Results： CPK levels of all asphyxiated newborns were signifieanfly raised. CPK levels of 42 asphyxiated neonates who developed HIE were significanfly higher than the rest of the asphyxiated newborns （P 〈0. 01 ） . CPK values of 16 eases with moderate to severe HIE were signifieanfly higher than the rest eases with HIE. Serum ＂CPK levels of 39 asphyxiated newborns who developed the multiple organ dysfunetion syndrome （MODS） were markedly higher than the rest of asphyxiated newborns. Condusion： Serum CPK might be helpful to forecast asphyxiated neonates will devel- op HIE and MODS or not, and the degree of HIE.