HbF与儿童急性白血病的预后

BLOOD FETAL HEMOGLOBIN AND PROGNOSIS IN CHILDREN WITH ACUTE LEUKEMIA

本文用抗硷血红蛋白法测定了３９例急性白血病患儿胎儿血红蛋白（ＨＢＦ）含量。结果示：２９例急性淋巴细胞白血病（Ａｌｌ）ＨｂＦ平均值为３．１５％，１０例急性非淋巴细胞白血病（ＡＮＬＬ）ＨｂＦ平均值为５．２１％，均有轻度增高，且经统计学处理，ＡＮＬＬ较ＡＬＬ为高，差异有显著性意义；相关分析示ＨｂＦ含量与缓解后初次复发的时间的负相关关系有显著意义；发病危险度的估计表明ＨｂＦ水平与急性白血病复发或死亡之间存在非常显著性关系。

Abstract:Fetal hemoglobin(HbF) level was examined by the alkali denaturation test in 39 children with acute leukemia. HbF mean value were 3. 15% in 29 acute lymphoblastic leukemia (ALL) patients and 5.21% in 10 acute non--lymphoblastic leukemia (ANLL) patients. They were all elevated moderatly. The value in ANLL was higher than that in ALL. The difference had significant in statistics;The correlation between HbF level and initial relapse or death was statistically significant (r=0. 6220,p<0. 01) ; The relatie risk analysis also indicated that the degree of increase in HbF was associated with the degree of malignancy.