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Nkx2.5基因与先天性心脏病的关系

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作者 张晶 朱鲜阳
出处 《沈阳部队医药》 2007年第2期134-136,共3页
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  • 1Hatcher C J, Kim M S, Basson C T. Atrial Form and Function: Lesson from Human Molecular Genetics.Trends Cardiovasc Med, 2000,10: 93 ~ 101
  • 2Pashmforoush M, Lu J T, Chen H, et al. Nkx2-5pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell, 2004,117: 373 ~ 386
  • 3Elliott D A, Kirk E P, Thomas Yeoh. Cardiac Homeobox Gene Nkx2. 5 Mutations and Congenital Heart Disease. J Am Coll Cardiol, 2003,41: 2072~ 2076
  • 4Elizabeth G E, Geiger E, Benson D W. Nkx2.5mutations in patients with tetralogy of fallot.Circulation, 2001,104 : 2565 ~ 2568
  • 5McElhinney D B, Geiger E, Blinder J, et al. Nkx2.5mutations in patients with congenital heart disease. J Am Coll Cardiol, 2003,42:1650~1655
  • 6Benson D W, Silberbach G M, McHugh A K, et al.Mutations in the cardiac transcription factor Nkx2.5affect diverse cardiac developmental pathways. J Clin Invest, 1999,104:1567~1573
  • 7Jay P Y, Harris B S, Maguire C T, et al. Nkx2-5mutation causes anatomic hypoplasia of the cardiac conduction system. J Clin Invest, 2004,113:1130~1137
  • 8Schott J J, Benson D W, Basson C T, et al. Congenital heart disease caused by mutations in the transcription factor Nkx2.5. Science, 1998,281 : 108~111

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