VEGF—C和HER一2在乳腺癌中表达的相关性

Relationship between VEGF - C and HER - 2 expressed in human breast cancer

目的探讨血管内皮细胞生长因子-c（VEGF—C）和HER-2在乳腺癌转移中的作用及其二者的相关性，为针对性的治疗提供依据。方法采用免疫组化S—P法检测42例乳腺癌组织中VEGF—C和HER-2的表达。在光镜下进行阳性细胞的计数和染色强度分级。结果42例乳腺癌组织VEGF—C阳性率为71．4％（30／42），HER-2阳性率为38．1％（16／42），VEGF—C阳性率转移组（90．9％）高于未转移组（50．0％），P〈0．01；HER-2的阳性表达与淋巴结转移也密切相关（P〈0．05）。VEGF—C比HER-2的阳性率高，16例HER-2表达阳性的病例中有15例VEGF—C的表达阳性（P〈0．05）。结论VEGF—C和HER-2的表达均与肿瘤细胞经淋巴管的转移密切相关，VEGF—C的表达有相对独立性，HER-2可以加强VEGF—C的表达。

Objective To study the relationship between vascular endothelia growth factor- C （ VEGF -C） and HER - 2 expressed in human breast cancer. Methods S - P immunobistochemical staining was used to detect the expression of VEGF - C and HER - 2 in 42 cases of primary breast cancer. Results Among 42 cases of breast cancer, the positivity rate of VEGF- C was 71.4% （30/42）. The positivity expression of VEGF -C in primary breast cancer with lymph node metastasis 90.9% was obviously higher than that in no lymph node metastasis cases 50.0% （ X^2= 6.70 〉 6.63, P 〈 0. 01 ） ; and HER - 2 was overexpressed in 38.1% （ 16/42 ） of breast cancer; HER - 2 expression level was correlated with lymph node metastasis （ X^2 = 4.95 〉 3.84, P 〈 0. 05）. The expression of VEGF -C in HER -2 positive breast cancer was significantly higher than that in HER- 2 negative breast cancer（ P 〈0.05）. Conclusion The expression of VEGF- C and HER-2 was related to local lymph node metastasis in primary breast cancer; VEGF -C can express in primary breast cancer independent. But the expression of HER -2 of tumor ceils can contribute to secretion of VEGF - C.