期刊文献+

nm23-H1和Cerb—B-2蛋白在骨肉瘤和良性骨肿瘤中的表达及意义

下载PDF
导出
摘要 目的探讨nm23-H1和Cerb—B-2蛋白在骨肉瘤和良性骨肿瘤中的表达。方法采用免疫组化SABC法检测48例骨肉瘤和20例良性骨肿瘤nm23-H1和Cerb—B-2蛋白表达。结果48例骨肉瘤nm23-H1和Cerb—B-2蛋白阳性表达率分别为31.3%和64.6%;20例良性骨肿瘤中nm23-H1和Cerb—B-2蛋白阳性表达率分别为80.0%和15.0%,骨肉瘤组织和良性骨肿瘤组织nm23-H1和Cerb—B-2蛋白表达差异均有统计学意义(P〈0.05),二者呈负相关。结论在骨肉瘤中nm23-H1蛋白的低表达和Cerb—B-2蛋白的高表达可能共同参与骨肉瘟的发生。
出处 《中原医刊》 2007年第6期51-52,共2页 Central Plains Medical Journal
  • 相关文献

参考文献14

  • 1王川,张祥福,杨发端,卢辉山,殷凤峙.nm23基因在食管癌中表达的免疫组化研究[J].肿瘤,1998,18(1):21-23. 被引量:18
  • 2许良中,杨文涛.免疫组织化学反应结果的判断标准[J].中国癌症杂志,1996,6(4):229-231. 被引量:1368
  • 3Sarris I, Scolyer RA, Konopka I, et al. Cytoplasmic expression of nm23 predicts the potential for cerebral metastsis in patients with primary cutanueos melanoma. Melanoma Res ,2004,14:23.
  • 4Nanashima A, Yano H, Yamaguchi H, et al. Immunohistochemical analysis of tumor biological factors in hepatocellular carcinoma : relationship to clinical pathological factors and prognosis after hepatic resection. J Gastroenteral,2004,39 : 148.
  • 5Hlupic L ,Jakic Razumovic J, Bozikov J, et al. Prognostic value of different factors in breast carcinoma. Tumori ,2004,90( 1 ) : 112.
  • 6Lacombe ML, Milon L, Munier A,et al. The human nm23 /nujcleoside diphosphate kinases. Bioenerg Biomembr, 2000, 32( 3 ) :247.
  • 7Soliani P, Ziegler S, Romani A, et al. Prognostic significance of nm23 gene product expression in patients with colorectal carcinoma treated with radical intent. OncolRep,2004,11 (6) : 1193.
  • 8Goncharuk VN, Del- Rosario A, Kren L, et al. Co- down regulation of PTEN,KAI- 1, and nm232H1 tumor metastasis suppressor proteins In non - small cell lung cancer. Ann Diagn Pathol, 2004,8:6.
  • 9Steeg PS. Perspectives on classic article: metastasis suppressor genes. J Natl Cancer Inst,2004,17:96.
  • 10Michael PD. Clinical significance of HER - 2/neuover expression : Part I. Principles & Practise of Oncology,1999,13( 1 ) :1.

二级参考文献3

共引文献1375

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部