(S)-4-叔丁基二甲基硅氧基-L-脯氨酰胺的合成

Synthesis of(S)-t-Butyldilnethylsilyloxy-L-Proline Amide

以光学活性反式-4-羟基-L-脯氨酸为原料,用苯甲氧羰酰基保护氨基,叔丁基二甲基,硅基保护羟基,然后与1,2-二苯基-2-氨基乙醇反应得到(S)-4-叔丁基二甲基硅氧基-N-苯甲氧羰酰-L-脯氨酰胺3,催化氢解得到(S)-4-叔丁基二甲基硅氧基-L-脯氨酰胺4.

（S）-4-hydroxy-L-Proline was N-protected using phenylmethyoxycarbonyl chloride and reacted with t- Butyldimethylsilyl chloride to give （S）-t-Butyldimethylsilyloxy N-phenylmethyoxycarbonyl-L-Proline 2, Which reacted with 2-amino-1,2-diphenylethanol to give L-Prolinamide 3. after hydrogenolysis, the L-prolinamide 4 was afforded.