α-环糊精包裹的前列地尔治疗椎基动脉供血不足的临床观察

Clinical observation of alprostadil alfadex on patients with vertebrobasilar insufficiency

目的观察α-环糊精包裹的前列地尔注射液治疗椎基动脉供血不足(VBI)的疗效。方法62例椎基动脉供血不足的患者分为前列地尔治疗组(30例)和丹参对照组(32例)。治疗组予α-环糊精包裹的前列地尔40μg加入生理盐水100ml静脉点滴,对照组予丹参20ml加入生理盐水250ml静脉点滴,均每天1次,连续14天。另外二组病人均给于肠溶阿司匹林、抗眩定、尼莫地平治疗。结果治疗组总有效率90%明显高于对照组71.9%(P<0.05)。结论α-环糊精包裹的前列地尔治疗椎基动脉供血不足效果明显。

Objective To observe the efficacy of alprostadil alfadex injection on patients with vertebrobasilar insufficiency. Methods 62 cases of vertebrobasilar insufficiency were divided into treatment group （alprostadil alfadex 30 cases ） and a control group （ Salvia mihiorrhiza 32 cases） . Patients in the treatment group received alprostadil alfadex （ alprostadil alfadex 40 μg in 100 ml saline, iv, gtt） daily for 14 day, while those in the control group were daily treated with salvia mihionrrhiza （ salvia mihiorrhiza 20 ml diluted in 250 ml saline, iv, gtt ） for 14 days. In addition, both group received conventional treatment with aspirin, betahistine and nimodipime. Results The overall efficacy of the treatment group （90%） is much higher than that of the control group （ 71.9% ） （ P 〈 0. 05 ） . Conclusion Alprostadil alfadex is effective in the treatment of vertebrobasilar insufficiency.