神经节苷脂GM_1治疗急性脑梗死疗效观察

The observation of clinical effects of ganglioside GM_1 in patients with acute brain infarction

目的探讨神经节苷脂GM1治疗急性脑梗死的临床疗效及其可能机制。方法51例急性脑梗死患者随机分成GM1治疗组及对照组。采用硫代巴比妥比色法及放射免疫法分别测定GM1治疗前后两组血浆丙二醛(MDA)及超氧化物歧化酶(SOD)水平,并评价其疗效。结果1.GM1治疗组较对照组血浆SOD活性明显恢复,血浆MDA明显降低P<0.05。2.GM1治疗组较对照组神经功能评分明显改善,日常生活活动能力明显提高P<0.01。结论神经节苷脂GM1通过增加酶自由基清除剂SOD的活性,减轻脂质过氧化反应,有效减轻缺氧性脑损伤。

objective to investigate the clinical effects and mechanism in patients with acute brain infarction by ganglloside GM1, Methods 51 cases were randomly divided to two group. The level of MDA and SOD were detected, Results 1.The active of MDA and the level of SOD in the group of GM1 treatment were more than the contrast group. 2.The grade of nerval function in the group of GM1 treatment was distinctly ameliorated and the ability of life was improved p〈0.01, Conclusions Ganglioside GM1 could increase the activity of SOD, lighten the reaction of lipid excessive oxidation and alleviate the encephalon damnification.