肿瘤标志物联合检测在多种肿瘤中的临床价值

Clinical value of combined testing of serum tumor markers in the diagnosis several tumors

目的调查肿瘤标志物联合检测在多种肿瘤中的临床价值。方法用肿瘤标志物芯片技术分析323例恶性肿瘤、369例良性病、122例正常对照血清中的12种肿瘤标志物的水平。结果323例恶性肿瘤中,215例肿瘤标志物阳性(65.3%);369例良性病中,63例肿瘤标志物阳性(17.1%);122例正常对照中,6例肿瘤标志物阳性(4.9%)。恶性肿瘤组的12种肿瘤标志物的联合检测阳性率显著高于良性病变组和健康对照组;肿瘤标志物联合检测对多种恶性肿瘤的检出率明显高于单一标志物的检测。结论肿瘤标志物联合检测有助于多种恶性肿瘤的诊断,并可用于肿瘤高危人群的筛查。

Objective The study was designed to investigate the Clinical value of combined testing of serum tumor markers in the diagnosis of several tumors. Methods 12 Tumor Markers of 323 cases with malignant tumor, 369 cases with non-tumor and 122 healthy persons were detected by using the technology of Protein Chip. Results The positive rate of malignant tumor group, non-tumor group and healthy person group was 65.3% （211/323）, 17.1%（63/369） and 4.9% （6/122） respectively. The positive rate of malignant tumor group was significantly higher than that of non-tumor group and healthy person group. Meanwhile, in the malignant tumor group, the rate of combined testing of tumor markers was significantly higher than most of single testing. Condusions Combined testing of serum tumor markers is helpful in both the diagnosis of several tumors and tumor screening for high risky persons.