HBV基因组表达对Ⅰ．Ⅲ型胶原转录的调控作用
被引量：1
EXPRESSIONOFHBVGENOMEANDITSEFFECTONTHEREGULATIONOFTHEmRNALEVELOFPROCOLLAGENTYPEANDTYPET
摘要
阐明肝炎后肝纤维化发生机制。方法以ＨＢＶ基因组转染细胞和转基因小鼠为模型，应用原位杂交技术和斑点杂交技术，研究ＨＢＶ基因组的表达对Ⅰ、Ⅲ型胶原ｍＲＮＡ含量的影响。结果ＨＢＶ基因组的表达能显著提高转染细胞内Ⅰ，Ⅲ型胶原ｍＲＮＡ的水平。结论ＨＢＶ感染能促进Ⅰ．Ⅲ型胶原的转录，诱导肝纤维化的发生。
出处
《中华肝脏病杂志》
CAS
CSCD
1996年第4期200-202,共3页
Chinese Journal of Hepatology
同被引文献25
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