盐酸纳洛酮治疗脑梗死的临床评价

Clinical Evaluation of Naloxone in The Cerebral Infarction

作者应用盐酸钠洛酮治疗38例脑梗死患者并以丹参治疗组作为对照，进行对比研究，结果纳格酮治疗组有效率89％，丹参组有效率64％，两者比较，存在着差异（P＜0．05）。提示早期合理使用盐酸钠洛酮（内源性吗啡样物质拮抗剂），可减轻、阻止甚至逆转由β-内啡肽所造成的局部脑缺血、水肿、梗死性病理过程．防止神经缺血性损害扩展。脑梗死发病24小时内使用纳洛酮，有效率90％。纳格酮始用量1．2mg·日-1·次-1，大剂量3．2mg·日-1·次-1，起效快，安全范围大，疗效高、毒副作用小，推荐用于脑梗死治疗的有效药物，值得在急诊推广应用。

Thirty-eight cases of cerebral infarction were treated with naloxene in early stage. All indices showed a significant difference in comparison with those of the controlls,e. g. Radix Salviae Miltiorrhizae group, (P <0.05). The results indicated that naloxone,antagonist of endogenous opium receptors could alleviate or stop,and even reverse the pathological process of ischemia and edema around the infarction regions,which were caused by pendorphin and could prevent the lesions from getting enlarged.Naloxone could regain consciousness and help the pathologic changes of nerve system to recover.The early use of naloxone in emergency treatment was recommended.