七氟醚吸入用于人工流产术对血浆肾素、血管紧张素Ⅰ、血管紧张素Ⅱ和皮质醇的影响

The effect of sevoflurane inhalation on plasma Rn,A-Ⅰ,A-Ⅱ and Cor during artiflcial abortion

目的观察单纯七氟醚吸入用于人工流产术的血压、心率和血浆肾素(Rn)、血管紧张素Ⅰ(A-Ⅰ)、血管紧张素Ⅱ(A-Ⅱ)、皮质醇(Cor)的变化。方法选择门诊人流术病人20例,用6%～8%七氟醚和5L/min氧流量诱导,病人入睡后继续使用2%～3%和3L/min氧流量麻醉维持。连续观察SBP、DBP、MAP、HR以及麻醉诱导前和术毕即刻的Rn、A-Ⅰ、A-Ⅱ及Cor浓度变化。结果术后SBP、MAP、HR较麻醉前有明显降低,A-Ⅰ、A-Ⅱ较麻醉前有显著升高(P<0.05)。结论七氟醚诱导迅速平稳,苏醒快且安全,适用于门诊人流等一些短小手术。但是单纯七氟醚吸入麻醉不能完全抑制人工流产术的应激反应。

Objective To evaluate the effect of sevoflurane inhalation on artificial abortion. Methods Twenty patients undergoing artificial abortion were given 6 %-8% sevoflurane and 5 L/rain O2 inhalation for induction. 2 %-3% sevoflurane and 3 L/rain O2 inhalation for the maintance of anesthesia. SBP,DBP,MAP and HR were recorded. The concentration of plasma rennin,hypertensin Ⅰ , hypertensin Ⅱ and cortisol were determined before induction and after operation. Results After operation, the level of SBP, MAP, HR were lower than before induction. After operation, the concentration of A- Ⅰ and A- Ⅱ were significantly higher. Conclusion Anesthesia induction and maintained with sevoflurane inhalation suitable for outpatients undergoing short and minor operation with smooth induction and quick recovery, but can not completely suppress the stress response to artificial abortion.