慢性乙肝湿热蕴脾证患者CD细胞、NK细胞功能的研究

Study on Functions of CD Cells and NK Cells in Patients with Chronic Hepatitis B of Damp-heat Retention Spleen Syndrome

探讨CD细胞、NK细胞功能在慢性乙肝湿热蕴脾证病理变化中的作用。选择慢性乙型肝炎湿热蕴脾证患者60例,随机分为2组,分别在治疗前和治疗1个月后检测CD3、CD4、CD8、NK细胞水平,并观察治疗前后中医证候疗效。结果表明慢性乙肝湿热蕴脾证患者CD3、CD4明显低于正常值,CD8明显高于正常值,治疗后均得到明显好转,2组治疗前后比较CD3、CD4、CD8值差异有显著性(P<0.01),NK细胞与正常值相比差异无显著性(P>0.05)。提示CD细胞功能异常是慢性乙肝湿热蕴脾证病理变化的重要因素之一,而NK细胞似乎与慢性乙肝湿热蕴脾证的病理变化关系不大;中医辨证治疗能有效地调节慢性乙肝湿热蕴脾证患者的CD细胞功能。

To explore the functions of the CD cells and NK cells on the pathologic variety of chronic hepatitis B （CHB） with damp-heat retention spleen syndrome （DH）. 60 patients were randomly divided into routine treatment group and TCM differentiation treatment group, and the values of CD3, CD4, CD8, the NK ceils were measured before and one month after treatment. The results showed that the levels of CD3, CD4 were lower than normal value, and CD8 was higher, they were became better after treament, there were obvious difference in two groups （P〈0.01）; there was no obvious difference in NK cells compared with normal value （P〉0.05）. It demonstrated that the disfunction of CD cells is an important factor in CHB with DH, but the NK ceils has nothing with it. Treatment according to TCM differentiation can avaihbly regulate the function of CD cells in CH.B with DH.