中草药对香烟中烟雾毒害的解毒作用研究

Clinical study of treatment with Chinese herbal medicine on elimination of tobacco poison and its smoke

目的:探讨中草药对香烟中烟雾毒害的化解疗效,为临床应用提供科学依据。方法:1动物实验:50只小鼠用灌服烟焦油制备模型,然后随机分为两组,模型对照组20只灌服5 ml葡萄糖,中药实验组30只灌服中草药液解毒,观察两组动物的生存情况。2临床试验选择10例志愿者。选择168例有吸烟史的门诊及住院患者连续观察3个月,试验期间吸烟不减量并口服中草药液;观察临床症状、体证、X线胸片或CT、心电图ST-T变化、肝功能、血或尿常规等。结果:1动物实验中中药实验组存活率为93.3%(28/30只),模型对照组20只全部死亡。2临床试验中预试验时10例志愿者两组症状改善情况差异有显著性。168例吸烟者1个月后85例阵发性咳嗽、咯黑色黏痰等临床症状消除,2个月后123例症状消除,3个月后138例症状消除。84例心电图ST-T改变者中1个月内恢复21例,2个月恢复35例,3个月恢复45例。CT或X线胸片1个月有效89例,2个月有效140例,3个月有效150例。3个月中无一例肝功能、血常规、尿常规出现异常。结论:中草药液能消除香烟烟雾造成的临床症状,减轻毒害,促进心肺康复,稳定内环境,有明显效果和临床实用意义。

Objective： To investigate the curative effect of Chinese herbal medicine on elimination of tobacco poison and its smoke, and prepare scientific evidence for clinical application. Methods： ① Animal experiment： The mice model was reproduced by drenching tobacco tar. Fifty mice were randomly divided into two groups., control group （received 50% glucose 5 ml, n= 20） and Chinese medicine treatment group （received distillate 5 ml ＋ Chinese herbal mixed liquor 5 ml/h） to observe their survival condition. ②Ten volunteers were involved in for preliminary experiment. One hundred and sixty -eight patients with tobacco smoking history in the out -patient department or admitted in the ward received Chinese herbal medicine orally to sequentially observe their condition for 3 months. During the experimental period, the smoking quantity of tobacco was not decreased, and the relief of clinical syndromes, signs, changes of chest X - ray or CT, electrocardiogram （ECG） ST- T, liver function, blood and urine routine examinations were analyzed by statistical treatment. Results： ①The survival rate of mice in the treatment group was 93. 3% （28/30）, while in the control group the mortality was 100% （20/20）. ②There was significant difference of improvement of clinical syndrome in 10 volunteers between two groups. In the 168 smokers, the clinical symptoms of paroxysmal cough, black sticky sputum etc. were relieved in 85 cases after 1 month of treatment, in 123 cases after 2 months of treatment and in 138 cases after 3 months of treatment. In the 84 cases with ECG ST - T changes, 21, 35 and 45 cases were recovered after 1 month, 2 months and 3 months of treatment respectively. The numbers of patients with improvememt were 89 cases after 1 month, 140 cases after 2 months and 150 cases after 3 months detected by chest X - ray or CT. In the 3 months, there were no abnormalities in liver function, blood and urine routine examinations in any case. Conclusion.. Chinese herbal medicine can relief clinical syndromes induced by tobacco, ameliorate tobacco poisoning, promote rehabilitation of heart and lung function, stabilize internal environment and remove toxin with obvious curative effect and clinical significance.