腐植酸与软骨损伤关系的研究进展

Research advance on relation between humic acid and chondrocyte injuries

大骨节病是一种原因不明的地方性、变形性骨关节病,饮水中有机物(主要是腐植酸)中毒是其主要病因学说之一。目前腐植酸与大骨节病的关系主要是腐植酸是否对软骨存在损伤作用的研究较多,但意见不统一,为提高其认识,对腐植酸与软骨损伤的关系进行综述。

Kashin-Beck disease （KBD） is a chronic osteoarthritic disease, and a endemic in parts of China, its etiology is unknown. Humic substance in drinking water has been proposed as one of the causative factors of KBD. At present, many studies on humic acid and chondrocyte injuries were reported. In this article, the progress of humic acid and chondrocyte injuries were reviewed.