口服降糖药的遗传药理学研究进展

Progress and research in pharmacogenetics of oral antidiabetic drugs

糖尿病是一种受多基因和环境因素共同影响的代谢性疾病。药物代谢酶、受体和转运体的遗传多态性对口服降糖药的体内代谢和降糖疗效有重要作用。本文从细胞色素P450酶、转运体和受体多态性方面对5种主要口服降糖药(磺脲类、噻唑烷二酮类、氯茴苯酸类、双胍类、α-葡萄糖甙酶抑制剂)的体内代谢和药物效应的影响作一综述。

Diabetes mellitus is a metabolic disease influenced by numerous genes and environmental factors. The genetic polymorphisms of drug-metabolizing enzymes, transporters or receptors play very important roles in the metabolism and therapeutical efficacy of oral antidiabetic drugs. In this review, we summarized the effects of genetic polymorphisms of certain CYP450 enzymes, transporters or receptors on the drug metabolism and efficacy of oral antidiabetic drugs including sulfonylureas, thiazolidinediones, meglitinide analogues, biguanides and aglucosaccharase inhibitors.