鱼腥草对致热大鼠下丘脑cAMP和腹中隔区精氨酸加压素含量的影响

Effects of Yuxingcao injection on contents of cAMP in hypothalamus and AVP in ventral septal area in fever rats

目的:探讨鱼腥草注射液的解热机制。方法:用酵母混悬液复制大鼠发热模型,观察鱼腥草注射液的解热作用及其量效关系,并采用放射免疫法检测下丘脑组织中cAMP及腹中隔区精氨酸加压素(arginine vasopressin,AVP)含量的变化。结果:鱼腥草注射液有明显的解热作用,并能抑制下丘脑中cAMP含量的升高,促进腹中隔区AVP的释放。相关分析显示,下丘脑中cAMP含量及腹中隔区AVP含量的变化与体温变化之间呈明显正相关。结论:鱼腥草注射液可通过抑制下丘脑中cAMP含量的升高及促进腹中隔区AVP的释放而发挥解热作用,并存在量效关系。

AIM： To explore the antipyrefic mechanisms of Yuxingcao injection in rats. METHODS： The fever model was made by suspension of yeast which was injected hypodemically to the rats. The contents of cAMP in hypothalamus and AVP in ventral septal area（VSA） were measured by radioisotope method. RESULTS： Yuxingcao injection possessed obvious antipyrefic effect on fever rats and inhibited the increase of cAMP in hypothalamus and promoted the release of AVP in VSA. Correlation analysis showed that contents of cAMP in hypothalamus and AVP in VSA were positively correlated with the change of body temperature of rats. CONCLUSION： The antipyretic mechanisms of Yuxingcao injection may be due to inhibiting the increase in cAMP in hypothalamus and promoting the release of AVP in VSA, and the effects are dosage-dependence.