复方磷酸可待因溶液治疗稳定期慢性阻塞性肺病患者的作用评价

Efficacy of compound codeine phosphate liquor on patients in the stable phase of chronic obstructive pulmonary disease

目的:探讨复方磷酸可待因溶液(奥亭止咳露)在稳定期慢性阻塞性肺疾病(COPD)中的辅助治疗作用。方法:共研究稳定期COPD患者120例,分3组,其中奥亭组(A组)40例,奥亭+氨溴索组(B组)40例,氨溴索组(C组)40例。各组年龄、症状等一般资料无明显差异,均用药7d。比较治疗前及服药后第4、8天时症状评分,并判定疗效。结果:3组各种症状在第4天均有不同程度的改善,第8天则更明显。治疗后总的症状评分与治疗前比较有明显改善(P<0.001),同时夜间睡眠改善。所有患者均未出现明显不良反应。结论:奥亭止咳露单用或联用氨溴索均可有效改善稳定期COPD患者的症状、改善睡眠质量,是有效辅助治疗药物之一。

Objective To study the efficacy of compound codeine phosphate liquor （Cofetol） on patients in the stable phase of chronic obstructive pulmonary disease （COPD）. Methods One hundred and twenty cases of stable phase COPD were divided into 3 groups, 40 treated with Cofetol （10 nd, rid） for 7 d （group A）, 40 treated with Cofetol （10 ml, rid） plus ambroxol pill （30 mg, rid） for 7 d （group B） and 40 treated with ambroxol pill （30 mg, rid） for 7 d （group C）. The symptom scores before and after the treatment were compared. Results In all the groups, the scores significantly improved on day 4 and day 8 after the treatment （P〈0.001）. Among all the symptoms, the sleep quality improved obviously. There was no side effect during the treatment. Conclusions Cofetol is one of the effective assistant agents in the treatment of stable phase COPD in single or combining use with the ambroxol pill by relieving the symptoms and to improving the sleep quality.