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针对表皮生长因子受体III型突变体靶向治疗肿瘤的研究进展

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摘要 表皮生长因子受体III型突变体(EGFRvIII)在许多类型肿瘤的发生发展中具有重要作用,它仅表达于肿瘤细胞,而正常细胞不表达,因此成为肿瘤治疗的理想靶点。现对EGFRvIII在肿瘤研究中的进展作一综述。
出处 《现代肿瘤医学》 CAS 2007年第4期557-560,共4页 Journal of Modern Oncology
基金 国家自然科学基金项目(编号:30600744)
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参考文献25

  • 1Sihto H,Puputti M,Pulli L,et al.Epidermal growth factor receptor domain Ⅱ,Ⅳ,and kinase domain mutations in human solid tumors[J].J Mol Med,2005,83(12):976 ~983.
  • 2Moscatello DK,Holgado-Madruga M,Emlet DR,et al.Constitutive activation of phosphatidylinositol 3-kinase by a natureally occurring mutant epidermal growth factor receptor[J].J Biol Chem,1998,273(1):200 ~206.
  • 3Ramnarain DB,Park S,Lee DY,et al.Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells[J].Cancer Res,2006,66(2):867 ~874.
  • 4Pedersen MW,Tkach V,Pedersen N,et al.Expression of a naturally occurring constitutively active variant of the epidermal growth factor receptor in mouse fibroblasts increases motility[J].Int.J Cancer,2004,108 (5):643 ~ 653.
  • 5Ning Y,Zeineldin R,Liu Y,et al.Down-regulation of integrin alpha2 surface expression by mutant epidermal growth factor receptor (EGFRvⅢ) induces aberrant cell spreading and focal adhesion formation[J].Cancer Res,2005,65 (20):9280 ~ 9286.
  • 6Li B,Yuan M,Kim IA,et al.Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin[J].Oncogene,2004,23(26):4594 ~4602.
  • 7Heimberger AB,Hlatky R,Suki D,et al.Prognostic effect of epidermal growth factor receptor and EGFRvⅢ in glioblastoma multiforme patients[J].Clin Cancer Res,2005,11 (4):1462 ~ 1466.
  • 8Montgomery RB.Antagonistic and agonistic effects of quinazoline tyrosine kinase inhibitors on mutant EGF receptor function[J].Int J Cancer,2002,101 (2):111 ~ 117.
  • 9Moscatello DK,Holgado-Madruga M,Emlet DR,et al.Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor[J].J Biol Chem,1998,273 (1):200 ~ 206.
  • 10Sampson JH,Crotty LE,Lee S,et al.Unarmed,tumor-specific monoclonal antibody effectively treats brain tumors[J].Proc Natl Acad Sci U S A,2000,97(13):7503 ~7508.

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