口服盐酸莫西沙星治疗非淋菌性尿道(宫颈)炎临床观察

Clinical efficacy of moxifloxacin for the treatment of nongonococcal urethritis/cervicitis

目的观察口服盐酸莫西沙星治疗非淋菌性尿道(宫颈)炎的临床疗效和安全性。方法沙眼衣原体或/和解脲脲原体感染引起的非淋菌性尿道(宫颈)炎患者504例,采用盐酸莫西沙星口服,每次400 mg,每日1次,连续12天。结果504例患者痊愈率为68.4%,总有效率为83.1%。沙眼衣原体和解脲脲原体感染清除率分别为84.8%和87.2%。不良反应发生率为7.9%。结论盐酸莫西沙星治疗非淋菌性尿道(宫颈)炎疗效好,安全性高。

Objective To evaluate the safety and efficacy of moxifloxacin in the treatment of non-gonococcal urethritis/cervicitis. Methods A total of 504 patients with nongonococcal urethritis/cervicitis due to Chlarnydia trachomalis （ CT ） or/and Ureaplasma urealyticum （ UU ） infection were enrolled. All patients were treated with oral moxifloxacin 400mg daily for 12 days. Resttlts The overall cure rate and response rate were 68.4% and 83.1%, respectively. The clearance rates of CT and UU were 84.8% and 87.2%, respectively. Moxifloxacin was well tolerated. The incidence of adverse events was 7.9%, and all adverse events were mild and reversible. Conclusion Moxifloxacin has high efficacy and safety in treating nongonococcal nrethritis/cervicitis.