丙戊酸钠对大鼠碳酸锂血清水平的影响

Study of effects of sodium valproate on serum lithium levels in rats

目的探讨丙戊酸钠对碳酸锂血清水平的影响。方法20只大鼠,♀♂各半,随机分成2组,每组各10只。研究组灌喂碳酸锂15 mg.d-15 d后,于d 6开始灌喂丙戊酸钠10 mg.d-1,2种药物共同灌喂3 wk;对照组仅喂碳酸锂15 mg.d-1。分别于d 5、12、19、26抽取尾血2 mL,用于测定碳酸锂血清水平。结果2组4次的碳酸锂血清水平分别是:研究组,(0.198±0.051)(、0.215±0.062)(、0.137±0.042)(、0.177±0.122)mmol.L-1,F=1.949,P=0.139;组内差异无显著性。对照组,(0.172±0.057)(、0.185±0.054)(、0.186±0.059)(、0.180±0.029)mmol.L-1,F=0.166,P=0.919;组内差异无显著性。研究组与对照组血清锂水平比较,仅第3次差异有统计学意义(P<0.05)。结论动物实验表明,丙戊酸钠对碳酸锂的血清水平几乎没有影响,不会引起碳酸锂水平的增高。

AIM To investigate the effect of sodium valproate on serum lithium level. METHODS Twenty rats were randomly divided into study group and control group. The rats in 2 groups were bred with 15 mg lithium carbonate every day for 26 d and the rats in study group were also bred with 10 mg sodium valproate every day from d 6 after using lithium carbonate until the ending of study. The tail blood was collected d 5,12,19,26 for determining serum lithium level. RESULTS The 4 time points serum lithium levels of rats in study group were（0.198±0.051）,（0.215±0.062）, （0.137±0.042）, （0. 177±0.122） mmol·L^-1, （F = 1.949, P = 0.139） respectively; and 4 time points serum lithium levels of rats in control group were（0. 172±0.057）, （0. 185±0. 054）, （0. 186±0.059）, （0.180±0.029） mmol·L^-1, （F = 0. 166, P = 0.919） respectively.The differences in serum lithium level between 2 groups were not significant except difference of third serum lithium level （ P 〈 0.05）. CONCLUSION Animal study indicates that sodium valproate don＇ t influence levels of serum lithium and don＇ t raise level of lithium carbonate in serum.