大黄和谷氨酰胺对重症患者血清细胞因子的影响

Rheubarb and Glutmine’s Influence on Severe Patients’Serum Cell Factors

[目的]观察大黄与谷氨酰胺(GLN)对危重病患者血清细胞因子和临床疗效的影响。[方法]对照组22例患者常规治疗;大黄组21例患者管饲生大黄粉30g/d;大黄+GLN组26例在给予生大黄粉30g/d的同时静注GLN40g/d。治疗7天。监测各组血清TNF-a、IL-6、IL-8指标变化及胃肠衰竭发生率和病死率。[结果]大黄+GLN组TNF-a、IL-6、IL-8明显降低(P<0.01、P<0.05)。肠衰竭发生数减少(P<0.05)。[结论]大黄鱼与GLN能抑制促炎因子的产生,减少胃肠功能衰竭。

[Objective]To observe the effect of Rheubarb and Glutmine（GLN）on the clinical cure and serum cell factors of severe patients. [Method]The control group 22 cases took routine treatment;the Rheubarb group 21 cases were fed with raw Rheubarb powder 30g/d by tube;the Rheubarb＋GLN group 26 cases took vein injection of GLN40g/d while fed with raw Rheubarb powder 30g/d. They were treated for 7 days. Observe the indexes of serum TNF-α,IL-6,IL-8,as well as gastro-intestinal failure rate and death rate. [Result]In the Rheubarb＋GLN group,TNF-α,IL-6 and IL-8 were reduced a lot（P〈0.01,P〈0.05）. The intestinal failure rate decreased（P〈0.05）. [Conslusion]Rheubarb and GLN can inhibit the production of inflammation-stimulating factors and decrease gastro-intestinal failure.