SPECT在抑郁症研究中的应用

The use of SPECT in the study of depression

功能显像是研究情感性精神障碍的有效手段。在抑郁症研究中常用的SPECT方法有灌注显像、代谢显像和受体显像，分别反映脑组织的血流、代谢情况及受体的分布和功能。数据处理方法有感兴趣区法和统计参数图法。主要综述各种显像和数据处理方法的特性、抑郁症患者SPECT脑显像的表现、血流异常的脑区及受体显像的发现，探讨SPECT在抑郁症发病机制研究中的应用，分析当前研究中存在的问题并对未来的研究进行展望。

Functional imaging is an effective methods in the study of psychological disturbances. The SPECT imaging methods commonly used in the study of depression are cerebral blood flow imaging, cerebral metabolic imaging and neuroreceptor imaging, which reflect the cerebral blood perfusion, cerebral metabolism, and the distribution and function of neuroreceptors respectively. The techniques in data processing include and statistical parametric mapping. This review summarizes the feature of the imaging and data processing methods, the manifestation of SPECT images in depressive patients, the brain region with abnormal blood flow and the findings in neuroreceptor imaging, analyzes the problems in current reports and prospects future studies.