^18F-氟脱氧葡萄糖和^11C-胆碱在孤立性肺结节诊断中的应用

Diagnostic uses for ^18F-fluorodeoxyglucose and ^11C-choline in single pulmonary nodules

^18F-．氟脱氧葡萄糖（^18F-FDG）和^11C-胆碱（^11C-choline）在孤立性肺结节（SPN）的定性诊断方面各有优势，两者联用可以互相弥补不足，效果较好。^18F-FDG对恶性SPN以及淋巴结转移判断的敏感性和特异性较高，^11C-胆碱可以降低炎性病变的假阳性率，有利于恶性SPN脑转移的诊断。但^11C-胆碱PET和^18F-FDGPET一样无法显示细支气管肺泡癌、小细胞肺癌等代谢较低的SPN。有报道，^18F-氟脱氧胸苷（^18F-FLT）可用于对肿瘤进行良恶性鉴别、疗效评估和预后判断，被认为是一种具有良好应用前景的PET显像剂。

For qualitation diagnosis of single pulmonary nodules （SPN）, both ^18F-fluorodeoxyglueose （ ^18F-FDG）PET and ^11C-choline PET have their own advantages. The outcome of the PET imaging will have more value for diagnosis if the two agents are used. ^18F-FDG PET has more high sensitivity and specificity for diagnosis of malignant SPN and metastasis of lymphonodes, ^11C-choline PET can decrease the false positive rate of inflamed foei and is helpful to diagnosis of brain metastasis from the malignant SPN. However, both agents can＇t be accumulated in bronehioalveolar carcinoma and small lung cancer with lower metabolism. It is reported that 3＇-deoxy-3＇-^18F-fluorothymidine （^18F-FLT） PET can be used to detect the benign nodes from the malignanee, evaluate the therapeutic effect and prognosis.^18F-FLT may be a prospective PET tracer in clinical applieation.