放射性脑损伤分子机制及神经保护策略研究进展

Radiated-induced brain injury： advance of molecular mechanisms and neuropr- otection strategies

放射性脑损伤（RBI）的潜在分子机制目前尚不完全清楚。RBI的形成是中枢神经系统内神经元、胶质细胞和血管内皮细胞之间复杂的、动态的相互作用过程。随着放射治疗的广泛应用，对RBI的神经保护治疗逐渐得到重视，提出了相应的神经保护策略。

The underlying mechanisms of radiated-induced brain injury （RBI） remain incompletely clear. Pathophysiological data indicate that the development of RBI involves complex and dynamic interactions between neurons, glia, and vascular endothehal cells within thecentral nervous system （CNS）. Radiated-induced injury in the CNS can be modulated by the therapies directed at altering steps in the cascade of events leading to the clinical expression of normal tissue injury. Some neuroprotective strategies are also addressed in the review.