硼中子俘获治疗的微剂量学研究现状

The current status of the microdosimetry study of boron neutron capture therapy

微剂量学研究在临床硼中子俘获治疗（BNCT）的计划设计和疗效评价中起着重要作用。设计一套既能准确描述10B化合物及其反应产生的次级粒子在细胞、亚细胞水平的剂量不均匀分布，又适合于临床上使用的微剂量估算模式，一直是此领域的研究重点。为此，着重介绍了BNCT的微剂量估算方法及其最近发现显著影响其精确度的因素。

Microdosimetry plays an important role in the clinical application of boron neutron capture therapy （BNCT）. There is increasing interest to develop a set of microdosimetry model, which can exactly describe the nonuniformly distribution of dose at cellar or sub-cellar level as well as conveniently used in clinic. In this paper, will give emphasis to the introduction of some common methods of microdosimtry and some affective factors reported in current reseaches on BNCT.