摘要
为了研究异体冻干脱钙骨基质在隆鼻术中的应用效果，作者利用正常新鲜四肢骨干皮质骨经脱脂、脱钙、清毒、冷冻干燥等过程，制备成冻干脱钙骨基质。动物实验中观察到将该种材料植于骨膜下和皮下时均有成骨现象，且植于骨膜下的成骨量优于皮下。临床上利用冻干脱钙骨基质进行隆鼻术，将该材料植于鼻骨表面，对１５例受术者中的８例进行了５～１８个月的随访，取得了较满意的效果。作者认为冻干脱钙骨基质有良好的诱导成骨作用，同时该材料易于雕刻修整，不发生排斥反应，能够长期保存。
Inordertoinvestigatetheefectoflyophilizedalogenicbonematrixinaugmentationrhinoplasty,ananimalexperimentandpreliminaryclinicalstudyhadbeendone.Thebonematrixwaspreparedasfolowingmainsteps:defatting,decalcification,sterilizationandfreeze-drying.Bonematrixisakindofbiomaterialwithosteogenicpotential,norejectionandsuitablemechnicalproperty.Inthereaearchonanimal,thebonematrixwasimplantedintosubperiostealandsubcutaneousinrabbits.Boneformationwasobservedafteroperation.Therefore,bonematrixwasusedasimplantinaugmentationrhinoplastyof15cases.Intheoperativeproceduretheimplantswerefixedonthenasalbone.8ofthe15casesweresatisfactoryduring5～18monthsfolow-upsbservation.Itprovedthatlyophilizedalo-genicdecalcifyingbonematrixisapromisingbiomaterialinaugmentationrhinoplasty.
关键词
异体冻干
脱钙骨基质
隆鼻术
DecalcifyingbonematrixAugmentationrhinoplasty
