摘要
目的:探讨卵巢上皮性肿瘤患者血浆溶血磷脂酸(LPA)水平及其潜在的临床应用价值。方法:采用生化法对70例卵巢上皮性肿瘤患者(恶性50例、良性20例)、20例正常妇女进行血浆LPA水平检测,同时测定血浆肿瘤相关抗原CA125水平。结果:正常妇女和良性卵巢上皮性肿瘤患者血浆LPA分别为(1.81±0.45)μmol/L、(2.23±0.37)μmol/L,恶性卵巢上皮性肿瘤患者血浆LPA水平高于正常妇女和良性卵巢上皮性肿瘤患者(P<0.05)。血浆LPA水平对恶性卵巢上皮性肿瘤诊断的敏感性(96.0%)和特异性(87.5%)优于肿瘤相关抗原CA125。结论:恶性卵巢上皮性肿瘤患者血浆LPA水平明显升高,LPA有望成为卵巢上皮性肿瘤诊断的敏感指标。
Aim: To study the serum levels of lysophosphatidic acid(LPA) in patients with epithelial ovarian tumor and its potential clinical value. Methods:70 patients with epithelial ovarian tumor (50 malignant cases, 20 benign cases) , 20 normal women were subjected to detect the serum levels of LPA and CA125. Results: Levels of serum LPA in patients with malignant cases were higher significantly than those of normal women and benign cases ( P 〈 0.05 ). The sensitivity (96.0%) and the specificity ( 87.5% ) of LPA in epithelial ovarian cancer diagnosis were superior to CA125 ( P 〈 0.05 ). Conclusion : Serum levels of LPA in patients with epithelial ovarian cancer were high significantly. LPA may be a potential biomarker for diagnosis of epithelial ovarian cancer.
出处
《郑州大学学报(医学版)》
CAS
北大核心
2007年第2期226-228,共3页
Journal of Zhengzhou University(Medical Sciences)
基金
国家自然科学基金资助项目30571948