卵巢上皮性肿瘤患者血浆溶血磷脂酸水平测定

Detection of serum level of lysophosphatidic acid of patients with epithelial ovarian tumor

目的:探讨卵巢上皮性肿瘤患者血浆溶血磷脂酸(LPA)水平及其潜在的临床应用价值。方法:采用生化法对70例卵巢上皮性肿瘤患者(恶性50例、良性20例)、20例正常妇女进行血浆LPA水平检测,同时测定血浆肿瘤相关抗原CA125水平。结果:正常妇女和良性卵巢上皮性肿瘤患者血浆LPA分别为(1.81±0.45)μmol/L、(2.23±0.37)μmol/L,恶性卵巢上皮性肿瘤患者血浆LPA水平高于正常妇女和良性卵巢上皮性肿瘤患者(P<0.05)。血浆LPA水平对恶性卵巢上皮性肿瘤诊断的敏感性(96.0%)和特异性(87.5%)优于肿瘤相关抗原CA125。结论:恶性卵巢上皮性肿瘤患者血浆LPA水平明显升高,LPA有望成为卵巢上皮性肿瘤诊断的敏感指标。

Aim： To study the serum levels of lysophosphatidic acid（LPA） in patients with epithelial ovarian tumor and its potential clinical value. Methods：70 patients with epithelial ovarian tumor （50 malignant cases, 20 benign cases） , 20 normal women were subjected to detect the serum levels of LPA and CA125. Results： Levels of serum LPA in patients with malignant cases were higher significantly than those of normal women and benign cases （ P 〈 0.05 ）. The sensitivity （96.0%） and the specificity （ 87.5% ） of LPA in epithelial ovarian cancer diagnosis were superior to CA125 （ P 〈 0.05 ）. Conclusion ： Serum levels of LPA in patients with epithelial ovarian cancer were high significantly. LPA may be a potential biomarker for diagnosis of epithelial ovarian cancer.