2,4,6–三甲基苯甲酸的合成

Synthesis of 2, 4, 6-trimethylbenzoic acid

考察了在以均三甲苯为原料、CO2和AlCl3为酰化剂经Friedel-Crafts酰基化反应、水解合成2,4,6-三甲基苯甲酸工艺过程中,物料配比、反应温度等反应条件对收率的影响,确定了适宜的反应条件和后处理条件。通过此合成工艺,产品的产率可达83.3%。

In this paper 2, 4, 6-trimethylbenzoic acid was synthesized by carboxylation of mesitylene in carbon dioxide-AlCl3 system. To optimize reaction conditions, experimental variables including reaction temperature and molar ratio were studied. The results showed the yield was as high as 83.3% when the molar ratio of mesitylene and AlCl3 was 0.7 ： 1 at room temperature.