N,N-双烷基壳聚糖结构对其自组装泡囊性质的影响

Effects of structure on N,N-dialkyl chitosan self-assembled vesicles

合成了不同主链相对分子质量的N,N-双辛烷基壳聚糖,N,N-双癸烷基壳聚糖及N,N-双十二烷基壳聚糖,并制备了相应的自组装泡囊,比较研究了侧链长度和主链相对分子质量对载药泡囊药物释放行为的影响。结果表明这类N,N-双长链烷基壳聚糖可形成粒径为100～150 nm的泡囊。原子力显微镜表明,侧链长度对N,N-双烷基壳聚糖泡囊的曲率有较明显影响,主链相对分子质量对泡囊的粒径影响较大。药物释放行为表明,侧链长度或主链相对分子质量的增大会导致药物释放速率的降低,达到平衡时的药物释放率也较低,而其相应自组装泡囊的载药量和包埋率却有所提高。

N,N-dioctyl, -didecyl, -didodecyl chitosans with different backbone molecular weight were synthesized. A comparative study on the drug release behavior of corresponding self-assembled vesicles was carded out. Morphology studies showed that the curve of N,N-dialkyl chitosan was depended on the length of side chain, and the backbone molecular weight influenced the size of corresponding vesicle. Experimental results of drug release indicated that the drug-releasing rates of vesicles made from longer alkyl chain and/or larger backbone molecular weight of chitosan were slower than the others, and drug-releasing equilibrium amount was smaller as well. Moreover, both drug loading content and encapsulation efficiency of vesicles slightly increased with the length of alkyl chain and/or the backbone molecular weight.