氟西汀治疗脑卒中后抑郁症32例临床观察

Clinical Observation of Fluoxetine in the Treatment of Post-stroke Depression

目的观察氟西汀治疗脑卒中后抑郁症的临床疗效。方法对64例脑卒中后抑郁症患者随机分为治疗组(氟西汀治疗)和对照组(常规治疗),各32例,进行对照观察,治疗前后行汉密尔顿抑郁量表(HAMD),日常生活能力Barthel指数(B I)量表及神经功能缺损评分(SSS)量表进行评定其疗效。结果治疗组HAMD治疗后评分(15.1±1.4)与治疗前评分(20.6±3.8)显著下降(P<0.01),对照组治疗后评分(16.3±2.5)与治疗前评分(21.8±3.4)比较差异无统计学意义(P>0.05),治疗组治疗后SSS评分显著降低,B I评分显著增高,与对照组比较差异有统计学意义(均P<0.01)。结论抗抑郁药物氟西汀治疗脑卒中后抑郁不仅对抑郁有明显效果,且可促进脑卒中后神经功能的恢复。

Objective To observe the clinical effect of fluoxetine in the treatment of post-stroke depression. Methods 64 patients with post-stroke depression were randomly divided into treatment group （ fluoxetine treatment, n = 32 ） and control group （conventional treatment, n = 32 ）. The curative effect was evaluated by the Hamilton rating scale for depression （HAMD）, The index of activity of daily living （ Barthel Index, BI） , and Scandinavian Stroke Score （ SSS ）. Results In treatment group, the HAMD was 15.1～ 1.4 after treatment, which was lower than 20. 6～ 3.8 before treatment（ P 〈 0. 01 ）. The SSS was decreased and BI was increased, comparing with control group, they had statistically significant difference （ P 〈 0.01 ）. However the HAMD in control group was not significant difference prior and post treatment （ P 〉 0.05 ）. Conchlsions The antidepressantfluoxetine in the treatment of post-stroke depression not only has remarkable antidepressive effect but also can improve the neurofunctional restoration.