纳多洛尔合成研究的改进

Improvement on Synthesis of Nadolol

以α-萘酚为原料，经过还原、酰化、氧化、醚化和胺化等一系列步骤制备了纳多洛尔。5，8-二氢-1-萘酚的收率为93．9％，熔点68～69℃；顺-5，6，7，8-四氢-6，7-二羟基．1．萘酚的收率为54．3％，熔点181—183℃；顺-5，6，7，8-四氢巧，7-二羟基-1-环氧丙基萘酚的收率为86．9％；纳多洛尔的收率为77％，熔点121—123℃。并用HNMR对顺-5，6，7，8-四氢击，7-二羟基-1-萘酚、顺-5，6，7，8-四氢-6，7-二羟基-1-环氧丙基萘酚和纳多洛尔进行了确证。

Using α-naphthol as raw material, nadolol was synthesized through reaction steps comprising of reduction, acylation, oxidation, etherification and amination. The yields and melting points of two following intermediates 5,8-dihydrogen-1-naphthol （ 1 ） and cis-5,6,7,8-tetrahydrogen-6,7-dihydroxy-l-naphthol （ 2 ） were 93.9% , 68 - 69℃ ; and 54. 3% , 181 - 183℃ respectively. The yield of cis-5,6,7,8-tetrahydrogen-6,7-dihydroxy-l-epoxypropylnaphthol （3） was 86.9% , and the yield and reciting point of final product nadolol were 77% and 121 - 123℃ respectively. The compounds of （2） , （3） and （4） were confirmed by 1HNMR.