胃癌组织中VEGF-C及其受体的表达与淋巴结转移的关系

VEGF-C and its receptor expression in gastric carcinoma and relationship with lymph node metastasis

目的探讨胃癌组织中VEGF-C、VEGFR-3的表达与胃癌淋巴转移的关系。方法采用免疫组化SP法检测54例胃癌组织及15例正常胃组织中VEGF-C及其受体VEGFR-3的表达。结果54例胃癌组织中,VEGF-C染色阳性者35例,阳性率为64.8%,而正常胃组织中VEGF-C的表达率仅为13.3%(2/15)。VEGF-C、VEGFR-3的表达与肿瘤大小、浸润深度、淋巴结转移及TNM分期呈明显正相关(P<0.05)。VEGF-C的表达在高-中分化腺癌和低分化腺癌的差异有显著性(P<0.05),VEGFR-3的表达与肿瘤分化程度的差异无显著性(P>0.05)。而且VEGF-C和VEGFR-3的表达呈显著正相关(P<0.01,r=0.699)。结论VEGF-C与VEGFR-3在胃癌的发生发展和淋巴结转移过程中起到协同促进的作用。通过阻断VEGF-C与VEGFR-3的结合途径有望降低胃癌的淋巴转移率,改善病人的预后。

[Objective] To explore the relationship between the expression of VEGF-C, VEGFR-3 and lymphatic metastasis in gastric cancer. [Methods] Immunohistochemistry （SP） was used to detect tho expression of VEGF-C and its receptor VEGFR-3 in 54 samples of gastric cancer and 15 samples of normal gastric tissue. [Results] In 54 gastric cancers, 35 samples were stained VEGF-C positive, which positive rates was 64.8%, while the positive rates of VEGF-C in normal gastric tissues was only 13.3% （2/15）. There were significantly inversely correlation between the expression of VEGF-C, VEGFR-3 and the size of tumor, the invasive depth, lymph node metastasis and TNM stage （P 〈0.05）. The expression of VEGF-C was of consanguineous correlation with the difference of high-middle and low differentiation （P 〈0.05）, while there was no consanguineous correlation between the expression of VEGFR- 3 and the differentiation degree of tumor （P 〉0.05）. And the expression of VEGF-C and VEGFR-3 was of significandy positive correlation （P 〈0.01, r =0.699）. [Conclusions] VEGF-C and VEGFR-3 had promoting effect in the happening, developing and lymph node metastasis of gastric cancer. It can reduce the lymph node metastasis probability of gastric cancer and improve the patient prognosis by interrupting the combination of VEGF-C and VEGFR- 3.